The acidity of tumors may hinder the effectiveness of treatments

Researchers from the University of Lisbon found that tumor acidity can hinder cancer drug effectiveness, potentially addressing chemotherapy resistance. Their computational models revealed that a decrease in pH significantly reduces drug entry into cancer cells. This discovery highlights how minor chemical changes can impact treatment efficacy without genetic resistance mechanisms. The team aims to confirm these findings experimentally and explore leveraging tumor acidity to enhance drug action. They are seeking funding and scientific partnerships for further testing.