Previously thought impossible: the pioneer of cell research grows mini-organs and tumor avatars

Organoids, often referred to as "mini-organs," are not merely tissue cultures but complex structures resembling actual human organs. Initially termed "mini-stomachs" to convey their nature, these organoids possess distinct shapes and three-dimensional structures made up of various cell types. The creation of organoids was once deemed impossible due to the Hayflick limit, which suggested that cells could only divide 40-60 times before aging and dying. This belief was a significant dogma in cell biology, hindering organoid development. However, advancements in technology have allowed researchers to overcome this limitation and understand tissue growth and repair better, paving the way for organoid creation.