Scientists slowed down the aging of mice. Research revealed an unknown role of bones

Researchers from Southern Medical University in China found that mechanical stimulation of bones can slow aging in mice. By disabling the PIEZO1 gene in osteocytes, mice showed accelerated aging signs, including memory decline and reduced lifespan. Conversely, applying controlled pressure to the bones of older mice improved their cognitive and physical abilities, increased muscle strength, and extended their lifespan by nearly 80 days. The study suggests that stimulated osteocytes release substances like PEDF, which may combat aging processes in other organs. Preliminary analyses indicate that PEDF levels decrease with age in humans, particularly in those with osteoporosis. The researchers hope their findings could lead to methods for slowing aging in individuals unable to exercise regularly.